Our aim is to better understand how cortical circuits malfunction in Autism, Epilepsy and Stroke. We study
- Structural and functional plasticity during motor learning and sensory (visual) stimulus encoding reliability in the MECP2-duplication model of Autism
- The role that different cell types play in epileptiform patterns of activity in the Stargazer Model of Absence Epilepsy and the Tetanus Toxin model of Focal Epilepsy
- Cortical circuit dysfunction in stroke
Abnormalities in experience dependent plasticity and excitation to inhibition balance have been implicated in circuit dysfunction in Autism. We use in vivo two-photon imaging to study changes in structural dendritic plasticity that occur during motor learning in the mouse model of the MECP2 duplication syndrome (PDF, PDF).
Other projects include
- M1 circuit malfunction during motor learning and with disease progression in MECP2-duplication syndrome
- Reliability of visual encoding in the MECP2-duplication syndrome of autism