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Our aim is to better understand how cortical circuits malfunction in Autism, Epilepsy and Stroke.  We study

  1. Structural and functional plasticity during motor learning and sensory (visual) stimulus encoding reliability in the MECP2-duplication model of Autism
  2. The role that different cell types play in epileptiform patterns of activity in the Stargazer Model of Absence Epilepsy and the Tetanus Toxin model of Focal Epilepsy
  3. Cortical circuit dysfunction in stroke


Abnormalities in experience dependent plasticity and excitation to inhibition balance have been implicated in circuit dysfunction in Autism. We use in vivo two-photon imaging to study changes in structural dendritic plasticity that occur during motor learning in the mouse model of the MECP2 duplication syndrome (PDF, PDF).


Other projects include

  • M1 circuit malfunction during motor learning and with disease progression in MECP2-duplication syndrome
  • Reliability of visual encoding in the MECP2-duplication syndrome of autism
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